Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): Regulation of the Expression of PARs
The level of receptors expressed on the cell surface determines the cellular responsiveness to agonists.Proteinase-activated receptors (PARs) have been reported to be either upregulated or down-regulated in response to various types of stimulation and pathological situations.In addition, the transcriptional regulation plays a major role in the alte